PPT Slide
1. Sparfloxacin IS the most active agent (intrinsically !! ) against intracellular Listeria m. ;)
2. Sparfloxacin activity is enhanced by the presence of ?-IFN (?-IFN and Sp DO cooperate !)
Listeria m., fluoroquinoles and ?-interferon
FQ move throughout the cell and
their activity is not defeated by pH
We don’t know the reasons…
Any suggestion ?? ( a big prize in Euros…)
Why don’t you use fluoroquinolones ?
- too low intrinsic activity ...