2d question (and answer): which antibiotics do or do not accumulate in cells ?

• beta-lactams: ? 1x

• aminoglycosides: ə to 2 x

• ansamycins: 2-3 x

• tetracyclines: 2-4 x

• fluoroquinolones: 5 - 20 x

• macrolides: 4 to > 100 x *

• glycopeptides: 1 to 400 x !! **

* azithromycin, ketolides

** LY 333328

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