Continu-infuus van ? - lactamen in intensieve zorgen: een amerikaanse studie…(3 g/dag)

(n=17)

Continuous

(n=17)

C max (mg/ml)

C min (mg/ml)

C mean (mg/ml)

t

˝

(h)

AUC

0-24h

Cl

t

(ml/min)

106.5 (34.6)

10.3 (16.0)

3.2 (2.5)

777.4 (474.6)

142.5 (58.7)

18.2 (6.5)

16.5 (5.7)

17.4 (6.1)

419.7 (141.5)

133.2 (37.0)

• Pharmacokinetocs and Pharmacodynamics of continuous and intermittent ceftazidime during the treatment of nosocomiale pneumonia. D.P. Nicolau et al. Clin Drug Invest 1999:18(2):133-139.

Intermittent

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