Dissocier les co-variables pharmacocinétiques

0

100

200

300

400

500

600

700

800

0

4

8

12

16

20

24

Temps (h)

Concentration, ng/mL

uniquotid.

3 x / jour

CIM 90

Pic / CMI ? ?

T > CMI ? ?

ASC / CMI =

Adapté de F. O. Ajayi, ISAP-FDA Workshop, 1999

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