Which patient and which value of AUC / MIC ?

creatinine AUC PK/PD

clearance (mg/l) (mg/L X h) Bkpt (mg/L)

100 56 0.5 2

50 98 0.8 4

An example with levofloxacin 500 mg qD

AUC / MIC

= 125

AUC / MIC

= 25

But the

peak remains

unchanged

at ? 5 mg /L