Combining it all …Peak/MIC = 10 and 24h-AUC / MIC = 125as predictors of efficacy standard doses of FQ ...

PK/PD Bkpts (mg/L)

Drug Dosage AUC/MIC peak / MIC

(mg/24h) (24h)

norfloxacin 800 0.1 0.2

ciprofloxacin 500 0.1 0.2

ofloxacin 400 0.2-0.4 0.3 - 0.4

levofloxacin 500 0.4 0.4 - 0.5

gatifloxacin 400 0.3 0.4

moxifloxacin 400 0.4 0.4

* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, LEVAQUIN®, TEQUIN®  and AVELOX®

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