Monte Carlo simulations of fluoroquinolone AUC / MIC against S. pneumoniae

• Probability of achieving free drug AUC / MIC ᡖ

  • levofloxacin 77.6?0.9%
  • gatifloxacin 97.5?0.4%
  • moxifloxacin 97.5?0.9%
    Owens et al, 2000

• Probability of achieving total drug AUC/MIC ratio of… ᡠ ᢈ

  • ciprofloxacin 4% 0%
  • levofloxacin 56% 6%
  • gatifloxacin 91% 33%
  • moxifloxacin 100% 100%
  • gemifloxacin 100% 100%
    Atkins et al, 2000

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