Modeling of the clinical data
Logistic Regression
- for evaluating the effects of covariates on outcome where the outcome measure is binary
Generalized Linear Modeling (GLM)
- multiple linear regression approach
Generalized Additive Modeling (GAM)
- models the dependence of outcome on the predictor variables
Tree based modeling
- An approach for understanding the predictive power of PD variables (clinical outcome, microbiological outcome)
Associating successes and failures to PK parameters
F. O. Ajayi, ISAP-FDA Workshop, 1999