Animal models

• Neutropenic mouse

• rabbit (endocarditis)

• rat, guinea pig, ...

Adapted from W.A. Craig, 2d ISAP Educational Workshop, 2000

The main advantage is the possibility to explore a

VERY large array of dosing regimens so as

• dissociate PK covariables (Cmax vs AUC …)

• explore the PK “conditions of failure”

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