Dilution models: a simple, useful system ...

MIC

Time Above MIC

Peak:MIC

AUC:MIC Ratio

Time

Drug Conc.

Inflow = Clearance

Fresh Medium

Waste

V

T1/2 = 0.693 * V/Cl

Sampling of Drug, Bacteria

Pump

Adapted from M.N. Dudley, ISAP / FDA Workshop, March 1st, 1999

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