Pharmacokinetic/ Pharmacodynamics: What are the goals ?
- Effectiveness: defining prospectively
- the daily dose(s) that will be effective;
- the optimal schedule;
- the risk of emergence of resistance
- Lack or minimization of adverse effects:
- drug uptake characteristics at the target organs
- influence of schedule and of repair between drug administration
- Prevention of resistance: evaluating propectively
- the risk of low doses and/or to high bkpts
- the importance of the rate of bacteral killing
- the potential for synergy
- the doses needed for intermediate organisms