Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation of Efficacy

The combination of 

• in vitro modeling,

• proper design of animal model experiments,

• pharmacokinetic information on patients in clinical trials

allows an in depth understanding of which aspects of drug exposure are most closely linked to

• therapeutic outcomes (successes as well as failures !!)

• quantifiable / predictable toxicity hazards

1st ISAP Discussion Workshop with Regulatory Authorities,

Rockville, MD, March 1st, 1999 (http://www.isap.org)

Previous slide

Next slide

Back to first slide

View graphic version