Continuous infusion of ceftazidime in ICU (3 g/day)
Intermittent
(n=17)
Continuous
(n=17)
C max (mg/ml)
C min (mg/ml)
C mean (mg/ml)
T
½
(h)
AUC
0-24h
Cl
t
(ml/min)
106.5 (34.6)
10.3 (16.0)
3.2 (2.5)
777.4 (474.6)
142.5 (58.7)
18.2 (6.5)
16.5 (5.7)
17.4 (6.1)
419.7 (141.5)
133.2 (37.0)
Pharmacokinetocs and Pharmacodynamics of continuous and intermittent ceftazidime during the treatment of nosocomial pneumonia. D.P. Nicolau et al. Clin Drug Invest 1999:18(2):133-139.