Active efflux of ciprofloxacin

Ciprofloxacin accumulation is facilitated

upon increase of its extracellular concentration

extracellular [ciprofloxacin] - 2h incubation at 37°C

0

1

2

3

0

1

2

3

4

log (mg/L)

cellular ciprofloxacin

log (mg/L)

2

4

9

17

34

68

136

2.5

7.5

12.5

mg/L

Cc/Ce

5.0

10.0

0

Michot et al., ICAAC 2000

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