Once-a-day schedule in cystic fibrosis ...
Cochrane Database Syst Rev 2000;(4):CD002009 Once daily versus multiple daily dosing with intravenous aminoglycosides for cystic fibrosis (Cochrane Review). Tan K, Bunn H.
Two trials (n=70 patients) qD vs tid
data on Forced Expiratory Volume at one second (FEV1), Forced Vital Capacity (FVC), nutritional status and side effects
no significant difference in efficacy or in the incidence of ototoxicity and nephrotoxicity