Is the once-a-day schedule used ?

Clin Infect Dis 2000 Mar;30(3):433-9

National survey of extended-interval aminoglycoside dosing (EIAD).

Chuck SK, Raber SR, Rodvold KA, Areff D.

• 500 acute care hospitals in the United States

• EIAD adopted in 3 of every 4 acute care hospitals

  • 4-fold increase since 1993
  • written guidelines for EIAD in 64% of all hospitals

• rationale

  • 87.1% : equal or less toxicity (),
  • 76.9% : equal efficacy
  • 65.6% :cost-savings

• dose: > 5 mg/Kg

• 47% used extended interval in case of decline in renal function (38% with Hartford nomogram)

Previous slide

Next slide

Back to first slide

View graphic version