The worldwide progress of the once-a-day made by clinicians ...
1989 - 1993: 14 comparative studies in all major indications showing = or > efficacy and = or < toxicity ? one mini-review in AAC (Gilbert, 1991) ? one ICAAC symposium ? FDA petition ? one re-registration (netilmicin)
1993 - 1999: 245 studies (? eff. ; ? tox) in almost every indication 8 meta-analyses supporting the once-a-day
? several editorials * ? inclusion in textbooks ** ? isepamicin is developped and registered once-a-day
* Gilbert, CID, 1997: “ there is no need of further studies…”
** In Mandell & assoc. (aminoglycoside chapter) as from 1995