Aminoglycosides in the 70’s ...
Potent antimicrobials but toxic ? nephrotoxicity (reversible) ? ototoxicity (irreversible)
All very similar biophysical, chemical, microbiological and pharmacokinetic properties, but...
- variable dosage (3 to 15 mg/kg)
- variable schedules (1 - 2 - 3 x/day … or even continuous infusion, …
“necessity” to monitor, but how ??