Cmax and MPC of FQ’s
Drug Dosage Cmax MPCa (mg/L)
(mg/24h) (mg/L) expected measur.
norfloxacin 800 2.4 * ~ 2.4
ciprofloxacin 500 2.4 * ~ 2.4
ofloxacin 400 3-4.5 *, + ~ 4.8
levofloxacin 500 5-6 *, + ~ 9.6 8.0
gatifloxacin 400 4 ~ 4.0 4.0
moxifloxacin 400 4.5 * ~ 1.4 2.0
a in Str. Pneumoniae (Blondeau et al., A.A.C. 45:433-438, 2001)
* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, LEVAQUIN®, TEQUIN®, and AVELOX®
+ first dose to equilibrium