To increase both AUC and peak … increase the unit dose ...

dosage AUC * PK/PD Peak * PK/PD qD mg*h/L Bkpt** mg /L Bkpt***

250 28 1 2.5 0.25

500 56 2 5 0.5

1000 112 4 10 1

* based on normal half-lifes; CL ~ 100 mg/dl; doses for an adult of 65 kg

** for a 24h AUC / MIC = 25

*** for a peak / MIC = 10

MIC

S. pneumoniae

~ 1-2 mg/L

An example with levofloxacin (qD)