Patients may be treatable because AUC (but not Cmax) increases with decreased drug clearance

creatinine AUC PK/PD

clearance (mg/l) (mgxh/L) Bkpt (mg/L)*

100 56 0.5

50 98 0.8

An example with levofloxacin 500 mg qD

* AUC / MIC

= 125

But the

peak remains

unchanged

at ? 5 mg /L