24h AUC / MIC and FQ effectiveness: in vitro dynamic models

• Antibacterial effect is correlated with drug exposure  (AUC) ;

• AUC / MIC is best predictor in inter- fluoroquinolones  comparisons;

• minor influence of the inoculum size;
  • Firsov et al., Antimicrob Agents Chemother 1998 42:2841-7
  • Firsov et al., Antimicrob Agents Chemother 1998 42:2848-52
  • Firsov et al., J Antimicrob Chemother 1999 43:483-90
  • Firsov et al., Antimicrob Agents Chemother 1999 43:498-502

• log change in viable counts is related to AUC / MIC ratio
  • McGowan et al., Antimicrob Agents Chemother 1999 43:1560-4

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