PK PD in action ...

Aminoglycosides 2d rule of tumb...

give them once-a-day to reduce toxicity

• 1h peaks of 12-18 mg/L for G, T, N

• 1h peaks of 20-30 mg/L for A, I

Increase interval ( ? 36h, ? 48h)

in case of renal failure

before reducing the unit dose...

Once-daily dosing of aminoglycoside antibiotics

Fisman, DN; Beth Israel Deaconess Med Ctr; Div Infect Dis; Harvard Univ, Sch Publ Hlth, Infectious-Disease-Clinics-of-North-America. Jun 2000

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