PK/PD and effectiveness:patterns of antimicrobial activity (after WA. Craig, 2000)

3. Concentration-dependent killing and  prolonged persistent effects (post-  antibiotic effect)

• Seen with aminoglycosides, quinolones, daptomycin, ketolides and amphotericin B
• Goal of dosing regimen: maximize concentrations
• AUC/MIC and Peak / MIC are major parameters correlating with efficacy

* 2d ISAP Educational Workshop,

Stockholm, Sweden, 2000

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