PK / PD in action...

?- lactams: 1st practical approach ...

• keep the interval but increase the unit dose...

If given

every 12 hours

(BID)

you ‘ll need

the following

amounts

to get

66% coverage at

250 mg

MIC ? 1.5

500 mg

MIC ? 3

750 mg

MIC ? 4.5

1000 mg

MIC ? 6

2000 mg

MIC ? 12

4000 mg

MIC ? 32

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