Improving ?-lactam efficacy by reducing the interval

time concentration for

(hours) 0.5 g 1 g 2 g

2 25 50 100

4 12.5 25 50

6 6 12 25

8 3 6 12

10 1.5 3 6

12 0.75 1.5 3

* single administration; 2h half-life; Vd = 0.2 l/kg; free fraction !!