Demonstrated advantages of animal models

Adapted from W.A. Craig, 2d ISAP Educational Workshop, 2000

• Is the magnitude of the parameter required for efficacy the same in different animal species?

YES

• Does the magnitude of the parameter vary with: 1. the dosing regimen? NO

2. different drugs within the same class? NO

3. different organisms ? Minimal

4. different sites of infection (e.g. blood, lung, peritoneum, soft tissue)? NO, but ...

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