Known PK problems (with solutions) linked with animal models
Serum clearance of most antimicrobials is faster in animals than in man
Serum protein binding is usually less in animals than in man
The higher doses required for studies in animal models may result in non-linear kinetics
Sensitive drug assays should be used to identify deep tissue compartments that could prolong activity against very susceptible organisms
Adapted from W.A. Craig, 2d ISAP Educational Workshop, 2000