A typical animal model to establish which PK parameters is associated with efficacy
- Use neutropenic murine thigh-and lung-infection models
- Evaluate 20-30 different dosing regimens (5 different total doses given at 4-6 different dosing intervals)
- Measure efficacy from change in Log10 CFU per thigh or lung at the end of 24 hours of therapy
- Correlate efficacy with various pharmacodynamic parameters (Time above MIC, peak/MIC, 24-Hr AUC/MIC)
Adapted from W.A. Craig, 2d ISAP Educational Workshop, 2000