Why in vitro dynamic models ...
Adapted from J. Mouton, 4th ISAP Educational Workshop, 2001
The goal is to establish basic relationships between drug exposure (PK) and effect (PD)
- PK:PD parameters for efficacy to apply across species, models, for combinations, etc...
- Basis of dosage in phase II trials
Limitations:
- Experimental conditions (laboursome; contamination; …)
- Usually only 1 or 2 days (effects ‘fade’ after 12-24 h)
- Haag factor ( biofilm…)
- a bsence of host factors (includ. protein binding and metabolism)
- ...