PK / PD of antibiotics in 2001 ?

• Much Basic Science is already available

  • review articlesCraig, Drusano, Schentag, Dalhoff, Zinner, Carbon, …1
  • chapters of booksMandell, Armstrong, …

• New drugs are being developped and registered with strong PK/PD bases

  • moxifloxacin (fluoroquinolone)
  • télithromycine (ketolide)
  • ...

• We need to apply the PK/PD principles to the existing drugs and/or to those wich have introduced recently without sound PK/PD bases

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