Transporters involved in the efflux of antibiotics from eucaryotic cells

superfamily transporter physiol. antibiotics substrates

ABC MDR1 phospholipids fluoroquinolones macrolides

b-lactams

tetracyclines

streptogramins

MRP1 phospholipids fluroquinolones

leukotrienes macrolides

conjugates rifamycins

MRP2 conjugates fluoroquinolones

b-lactams

MFS NPT1 phosphates b-lactams

OAT OATP1 bile salts b-lactams

steroids

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