Intracellular Antibiotic Kinetics and Dynamics : A Reflexion of Reality

7th  International symposium on New Quinolones, 10-12 June 2001, Edinburgh, Scotland

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Table of Contents

Intracellular Antibiotic Kinetics and Dynamics : A Reflexion of Reality

Why intracellular antibiotics ?

Intracellular antibiotics: the issues

Which antibiotics accumulate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

How do antibiotics penetrate in cells ?

Antibiotics efflux ?

Transporters - data bases 

Transporters involved in the efflux of antibiotics from eucaryotic cells

Most frequent antibiotic-pumps in eucaryotes (1/2)

Most frequent antibiotic-pumps in eucaryotes (2/2)

Evidencing active efflux ...

Evidencing active efflux ...

Active efflux of ciprofloxacin

Characterization of the transporter(s)

Not all fluoroquinolones are subject to active efflux ...

Subcellular localization ?

Mechanisms of localisation and accumulation ...

Mechanisms of localisation and accumulation ...

Mechanisms of localisation and accumulation ...

Mechanisms of localisation and accumulation ...

Subcellular bioavailability of antibiotics ?

Subcellular bioavailability of antibiotics ?

Subcellular bioavailability of antibiotics ?

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Intracellular infection cycle of Listeria monocytogenes hly+

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Activities of fluoroquinolones against intracellular Listeria m. (Michelet et al., AAC, 1997)

Improving the activity of fluoroquinolones by inhibiting efflux

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Author: Paul M. Tulkens 

Email: tulkens@facm.ucl.ac.be 

Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm

Other information:
These slides are for information only. Do not make public use of them without autorization. Please, adress your request to <tulkens@facm.ucl.ac.be> 

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