Accumulation des aminoglycosides dans les fibroblastes

Ce = 1.3 mg/ml

Ce = 0.65 mg/ml

Ce = 0.35 mg/ml

• lent (jours…)

• non-saturable

• peu efficace (2-4 fold)

• endocytose fluide ...

Tulkens & Trouet, Biochem. Pharmacol. 27:415-4241978

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