How do you get a given 24h-AUC ? 3. get a low clearance

the 24h-AUC is 

inversely proport. to the clearance

Use a drug with a long half-life

Thus...

24h-AUC =

(24h-Dose x Bav) / Cl

t1/2 = 6 h t1/2 = 2 h

Previous slide

Next slide

Back to first slide

View graphic version