Pharmacokinetics / pharmacodynamics as a step towards therapy...

19/06/00

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Table of Contents

PPT Slide

Pharmacokinetics / pharmacodynamics as a step towards therapy...

PK/PD parameters: a first sight

What does the clinician (and the patient) want ?

Pharmacokinetics ...

Pharmacodynamics ...

Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation of Efficacy (1/2)

PK/PD in drug develop-ment A view from FDA

Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation of Efficacy (2/2)

Pharmacokinetic/ Pharmacodynamics and antibiotic resistance...

PK/PD and drug devlop-ment A view from EMEA

Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation

Pharmacokinetic / Pharmacodynamic parameters: a 2d sight

PK/PD: role of concentration

PK/PD: role of concentration an example with Listeria monocytogenes

PK/PD: role of time 

PK/PD: prolonged effects 

PK/PD: role of prolonged effects 

PPT Slide

PPT Slide

How do you get a given 24h-AUC ? 1. importance of the dose (a)

How do you get a given 24h-AUC ? 1. administer the right dose...

How do you get a given 24h-AUC ? 2. give a dose frequently

How do you get a given 24h-AUC ? 3. get a low clearance

But isnít anything more ?

How to predict efficacy in the intracellular milieu ?

PPT Slide

How to predict efficacy in the intracellular milieu ?

And we may have a very bright future...

Author: Paul M. Tulkens 

Email: tulkens@facm.ucl.ac.be

Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm