Pharmacokinetics / pharmacodynamics as a step towards therapy...
PK/PD parameters: a first sight
What does the clinician (and the patient) want ?
Pharmacokinetics ...
Pharmacodynamics ...
Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation of Efficacy (1/2)
PK/PD in drug develop-ment A view from FDA
Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation of Efficacy (2/2)
Pharmacokinetic/ Pharmacodynamics and antibiotic resistance...
PK/PD and drug devlop-ment A view from EMEA
Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation
Pharmacokinetic / Pharmacodynamic parameters: a 2d sight
PK/PD: role of concentration
PK/PD: role of concentration an example with Listeria monocytogenes
PK/PD: role of time
PK/PD: prolonged effects
PK/PD: role of prolonged effects
PPT Slide
How do you get a given 24h-AUC ? 1. importance of the dose (a)
How do you get a given 24h-AUC ? 1. administer the right dose...
How do you get a given 24h-AUC ? 2. give a dose frequently
How do you get a given 24h-AUC ? 3. get a low clearance
But isn’t anything more ?
How to predict efficacy in the intracellular milieu ?
And we may have a very bright future...
Email: tulkens@facm.ucl.ac.be
Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm