PK/PD for prevention of resistance: clinical data
Infect Control Hosp Epidemiol 2000 Jan;21(1 Suppl):S9-11 … / ...
- Respiratory tract isolates had higher rates of ciprofloxacin resistance (12%) than isolates from other infection sites (4%).
- Respiratory tract isolates exposed to ciprofloxacin at AUIC24 < or =110 (microg x h/mL)/microg/mL had the highest resistance (17%).
- At AUIC24 (microg x h/mL)/microg/mL, resistance was decreased to 11%, a rate similar to that seen in respiratory isolates not exposed to ciprofloxacin (7%)