Peak concentrations as a tool to prevent emergence of resistance (MPC): using “ PK / PD acceptable ” MICs

Drug Dosage Cmax “PK/PD Bkpt” expect.

(mg/24h) (mg/L) (mg/L) MPC

norfloxacin 800 2.4 * 0.2 ~ 2.4

ciprofloxacin 500 2.4 * 0.2 ~ 2.4

ofloxacin 400 3-4.5 *, + 0.4 ~ 4.8

levofloxacin 500 5-6 *, + 0.8 ~ 9.6

gatifloxacin 400 4.2 * 0.4 ~ 1.4

moxifloxacin 400 4.5 * 0.4 ~ 1.4

* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, LEVAQUIN®, and AVELOX®

+ first dose to equilibrium

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