The design of an ideal antibiotic ...
Will it always be ideal ?
Main causes of antibiotic failures... Adapted from Pechère J.C., 1988, 1993, 1998
Pharmacokinetics / pharmacodynamics as a step towards therapy...
Pharmacokinetics ...
Pharmacodynamics ...
Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation of Efficacy (1/2)
PK/PD in drug develop-ment A view from FDA
Pharmacokinetic/ Pharmacodynamics and antibiotic resistance...
Are PK/PD important in resistance ?
Single dose PK/PD parameters: a first sight
Multiple doses: the issues...
Pharmacokinetic / Pharmacodynamic parameters: a 2d sight
Pharmacokinetic/ Pharmacodynamics
PK/PD patterns of antimicrobial activity (1 of 3) (after WA. Craig, 2000)
PK/PD patterns of antimicrobial activity (2 of 3) (after WA. Craig, 2000)
PK/PD patterns of antimicrobial activity (3 of 3) (after WA. Craig, 2000)
PK/PD: role of concentration Point of Principle an example with Listeria monocytogenes
The role of the peak for FQ : animal models
Peak concentrations of the main fluoroquinolones (p.o.)
Peak concentrations as a tool to determine acceptable sensitivities to fluoroquinolones (p.o.)
PK/PD of fluoroquinolones: role of the 24h-AUC MIC ciprofloxacin in hospital-acquired pneumonia
24h-AUC / MIC as a tool to determine acceptable sensitivities to fluoroquinolones (p.o.)
Peak concentrations and 24h-AUC / MIC as predictors of efficacy of FQ ...
But isn’t anything more about the peak ?
Fluoroquinolones: mode of action and resistance mechanisms
The importance of double mutation ...
Mutant-prevention concentration (MPC) (1/3)
Bactericidal activity of FQs against M. bovis
Mutant-prevention concentration (MPC) (2/3) ...
Role of the C8-methoxy in decreasing MPC
N-1-cyclopropyl-fluoroquinolones with a C8-methoxy
Peak concentrations as a tool to prevent emergence of resistance (MPC): using “ PK / PD acceptable ” MICs
PK/PD and antibiotic efflux pumps...
PK/PD and antibiotic efflux pumps… an example with RND...
PK/PD for prevention of resistance: clinical data
PPT Slide
And we may have a very bright future...
Email: tulkens@facm.ucl.ac.be
Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm