Intracellular accumulation of antibiotics: when is it good, when is it bad ?

September 20th, 2000

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Table of Contents

Toxicodynamics of New Chemical entities : Tools for the Safer Design, Selection and Use of New Antibiotics

Which antibiotics accumulate in cells ?

Where are intracellular antibiotics located ?

Antibiotic intracellular penetration how can they get there ? 

Antibiotic intracellular penetration how can they get there ? 

PPT Slide

Modeling of the accumulation of azithromycin in serum and PMN (500 mg/day)

Antibiotic efflux

PPT Slide

Antibiotic efflux pumps...

Fluoroquinolone efflux from macrophages…

Which bacteria ?…

Where do intracellular bacteria sojourn and thrive ? 

Antibiotic intracellular expression of activity

Accumulation and activity … an example with cytosolic Listeria m.

Cellular and tissular accumulation... When is it good ?

Cellular and tissular accumulation... When is it bad ?

Author: Paul M. Tulkens 

Email: tulkens@facm.ucl.ac.be

Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm