Pharmacokinetic modulation of intracellular activity: active efflux

Extrusion of antibiotics from the cytosol

2. Cellular pharmacodynamics

(cytosolic L. monocytogenes)

Intracellular activity

(log(CFU 0h/16h))

Ce CIP = MIC

Rudin et al, J Exp Med, 1992, 1439-1447