CONCENTRATION EFFECT RELATIONSHIPS FOR INTRACELLULAR MICRO-ORGANISMS :

12/06/2000


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Table of Contents

CONCENTRATION EFFECT RELATIONSHIPS FOR INTRACELLULAR MICRO-ORGANISMS :

These they are…

How to predict efficacy in the intracellular milieu ?

Can MIC be predictive ?

How to predict efficacy in the intracellular milieu ?

How to predict efficacy in the intracellular milieu ?

Pharmacokinetics : intracellular MIC ?

Pharmacokinetics : intracellular MIC ?

Why are acidic drugs excluded ?

Why do basic drugs accumulate ?

PPT Slide

Pharmacokinetic modulation of intracellular activity: drug trapping

Pharmacokinetic modulation of intracellular activity: drug trapping

Pharmacokinetic modulation of intracellular activity: active efflux

Pharmacokinetic modulation of intracellular activity: active efflux

Pharmacokinetic modulation of intracellular activity: active efflux

Pharmacokinetic modulation of intracellular activity: active efflux

Pharmacodynamics : intracellular MIC ?

Pharmacodynamics : intracellular MIC ?

Pharmacodynamics : intracellular MIC ?

Pharmacodynamic modulation of intracellular activity: expression of activity

Pharmacodynamic modulation of intracellular activity: cooperation - host defenses

Concentration - effect relationships for intracellular micro-organisms

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Author: F. Van Bambeke

Email: tulkens@facm.ucl.ac.be

Home Page: http://www.md.ucl.ac.be/facm