Gastrointestinal Safety and TolerabilityCelecoxib vs NSAIDs

• Gastroduodenal ulceration- 6 endoscopy studies in 򘖀 individuals

• Clinically significant upper GI events- 4004 patient-years exposure data (All treatments)

• Changes in haemoglobin

• GI Symptoms

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ᡃ,000 patients with OA  or RA in 14 Phase II / III

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