Actual results of drug interaction studies

Karim A et al. Arthritis & Rheum 1998;41(9) Suppl:1698A.

Data on File: Searle (Studies 017, 038, 039, 040, 050, 051,117)

No interactions with :

• methotrexate

• glyburide

• warfarin

• phenytoin

• tolbutamide

• ketoconazole

Interactions observed :

• lithium (17% increase AUC and Cmax)

• fluconazole (2x increase celecoxib AUC and Cmax by CYP 2C9 inhibition)

• paroxetine and dextromethorphan (moderate increases of PK values)

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