Inhibition of COX-1 is not anti-inflammatory or analgesic

Control

Vehicle

SC-560

celecoxib

0

0.3

0.6

0.9

1.2

1.5

0

3

6

9

12

15

Hyperalgesia

Edema

Pain Response

D Withdrawal Latency (sec)

D Paw Volume (ml)

Smith CJ, PNAS, 1998, 95, 13313-18

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