Phase III RA Trial Design

Rheumatoid Arthritis Flare

Celecoxib 400 mg 2x/d

Arthritis Assessments X X X X

Week 12

Celecoxib 200 mg 2x/d

Placebo BID

Celecoxib 100 mg 2x/d

Week 6

Week 2

Naproxen 500 mg 2x/d

Geis GS et al. Arthritis & Rheum 1998;41(9) Suppl:1990A

Searle Studies 022, 023