Phase III Pivotal OA Trials : Study Design

Placebo BID

Celecoxib 50 mg BID

Osteoarthritis Flare

Hip or Knee

Celecoxib 100 mg BID

Celecoxib 200 mg BID

Week 2

Week 12

Week 6

Naproxen 500mg BID

Hubbard R et al. Arthritis & Rheum 1998;41(9) Suppl:982A. Data on file: Searle Studies 020, 021, 054

Randomised &

double-blind

Physical Examination x x

Arthritis Assessments x x x x

Laboratory Tests x x x x