AUC24h / MIC and aminoglycosides ...

amikacin 15 mg/kg :

• once-a-day peak of 40 µg/ml

• you should be able to treat up to 4 µg/ml, don’t you ?

15 mg / kg / day

AUC24h ? 130

130 / 125

1

Is this the reason why aminoglycosides

can’t be used in monotherapy ?

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