? - lactams * in clinical practice: giving them more frequently

0 100

2 50

4 25

8 6

5:15 12

* model ? -lactam, 1g / 50kg with half-life of 2h and Vd = 0.2 l/kg

time concentr.

50 % ? 24 µg/ml

66 % ? 16 µg/ml

100 % ? 6 µg/ml

1 g every 8 h

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