PK/PD and resistance:cooperation with host defenses

2. a. Intracellular penetration  (are intracellular bacteria less susceptible ?

• beta-lactams: ? 1x

• aminoglycosides: ə to 2 x

• ansamycins: 2-3 x

• tetracyclines: 2-4 x

• fluoroquinolones: 10-20 x

• macrolides: 4 to > 100 x

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